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All Journal IPTEKMA Journal of Pharmaceutical Science and Application Syntax Literate : Jurnal Ilmiah Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Bali Health Journal Jurnal Kesmas (Kesehatan Masyarakat) Khatulistiwa Jurnal Jejaring Matematika dan Sains Jurnal Bali Membangun Bali Humantech : Jurnal Ilmiah Multidisiplin Indonesia
I Wayan Martadi Santika
Program Studi Farmasi, Fakultas Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Udayana, Bali
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Transportation Other

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Journal : Journal of Pharmaceutical Science and Application

 1 
ANTIFUNGAL ACTIVITIES OF ETHANOL EXTRACT OF ROSEMARY LEAF (Rosemarinus officinalis L.) AGAINST Candida albicans Dewa Ayu Made Adnya Swari; I Wayan Martadi Santika; I Gusti Made Aman
Journal Pharmaceutical Science and Application Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (599.817 KB) | DOI: 10.24843/JPSA.2020.v02.i01.p05

Abstract

Background: This study was a preliminary study aimed to investigating the in vitro activity of rosmarinic acid contained on Rosemary leaves (Rosemarinus officinalis L.) on the Candida albicans. Rosmarinic acid can be an inhibitor of the RTPase enzyme in the fungus Candida albicans. Objective: This study is expected to provide information in the development of science about the antifungal activity of ethanol extract of Rosemary leave (Rosmarinus officinalis L.) againsts C.albicans. The recent research was an laboratory experimental. Experiments on an ethanol extract of Rosemary leaves (Rosemarinus officinalis L.) and post-test design of the control group. Methods: The extraction method used in this study was a multilevel extraction method. The antifungal activity testing method uses discs and MIC methods. Replication was done six times at two concentration namely, 80% (b/v) and 100% for each measurement. Results: The data analysis was carried out using SPSS with 95% of confidence level with the Kruskal Wallis analysis then completed with the Mann Whitney U test. The results of the MIC experiment showed all the various concentrations of ethanol extract performed Candida albicans growth on the surface of the media. Extract with 80% (b/v) concentration showed greater antifungal activity. Furthermore the MIC was shown by 80% (b/v) concentration of the ethanol extract of Rosemary leaves against Candida albicans. The test results of the antifungal activity of the Rosemary leaf ethanol extract showed the presence of inhibitory diameter in the ethanol extract of the Rosemary leaf concentration of 80% (b/v) with a mean ± SD of 10.6 ± 0.57735 and RSD of 5.774%. Conclusion: The ethanol extract of Rosemary leaves (Rosmarinus officinalis L.) has an inhibitory effect on the fungus Candida albicans at a concentration of 80% (b / v) Keywords: Antifungal activity, Candida albicans, Rosemary, RTPase, ethanol extract
Co-Authors A.A.Kt. Sri Trisna Dewi W Dewa Ayu Made Adnya Swari I Gusti Made Aman I Made Agus Gelgel Wirasuta I Nyoman Arsana I Nyoman Kadjeng Widjaja I Putu Sudiartawan Ida Bagus Putra Suta Ida Bagus Wiryanatha Ketut Widyani Astuti Luh Putu Febryana Larasanty Luh Putu Febryana Larasanty Made Adi Wira Darma Made Krisna Adi Jaya Mita Ayu Wulandari Ni Kadek Ayu Arik Setyawati Ni Kadek Warditiani Ni Luh Gede Sudaryati Ni Made Widiastuti Ni Putu Aryati Suryaningsih Ni Putu Dewi Rahayuni Pande Made Nova Armita Putri, Dhiancinantyan Windydaca Brata Putu Eka Arimbawa Putu Eka Arimbawa Putu Lakustini Cahyaningrum Putu Sana Yustiantara